November 20, 2020
World Pancreatic Cancer Day 2020
To honor the Pancreatic Cancer Awareness Day (today) and Pancreatic Cancer Awareness Month (November) we are raising awareness about the symptoms and risks of this devastating disease and the urgent need for earlier detection.
The results of our first clinical trial testing CEND-1 in pancreatic cancer patients were published at the annual European cancer meeting ESMO 2020 and Annals of Oncology. We are now preparing to test CEND-1 in multi-center randomized clinical trials in pancreatic cancer patients and expand into additional indications in our effort to help patients with hard-to-treat solid tumors.
September 25, 2020
Cend Therapeutics Announces Acquisition of Impilo Therapeutics
San Diego, September 21, 2020 – Cend Therapeutics, Inc., a clinical-stage biotech company, announced today that it has acquired Impilo Therapeutics, Inc. The combination expands Cend’s drug delivery capabilities to create a unique platform for targeted tissue penetrating delivery of nucleic acid-based medicines to solid tumor cancers.
While antisense and siRNA medicines have reached market for a range of metabolic, neurological and neuro-muscular conditions, none have reached market for anticancer applications. “By combining Impilo with Cend our objective is to address delivery issues that have limited the ability of nucleic acid-based medicines to benefit cancer patients,” commented David Slack, CEO of Cend.
“Cend’s lead asset, CEND-1, has generated encouraging clinical data showing the ability to enhance delivery of standard-of-care chemotherapy for pancreatic cancer patients, and the Company has generated similarly encouraging preclinical results for a variety of therapeutic modalities,” commented Sangeeta Bhatia, MD, PhD, scientific co-founder of Impilo and Director of MIT’s Center for Cancer Nanomedicine.
“With the combination of Cend and Impilo technologies, we have demonstrated unique abilities to deliver antisense, siRNA, microRNA, and immunostimulatory oligonucleotides selectively to solid tumor cancers and certain immune cells,” commented Frank Slack, PhD, scientific cofounder of Impilo and Director of Harvard’s Initiative for RNA Medicine.
“The scientific founders of Cend and Impilo have collaborated for many years and generated significant publications” commented Cend Executive Chairman, Erkki Ruoslahti. “Cend will continue to work closely with Impilo’s founders as part of our extended team.”
Via acquisition of Impilo’s assets, the CendR PlatformÔ combines Cend’s clinical-stage targeted tumor penetrating peptide, CEND-1, with additional targeting capabilities. It also brings nanoparticle technologies, including fusogenic nanoparticles that can deliver high payloads of nucleic acid-based drugs directly into the cytosol compartment of cells.
Financial details of the transaction have not been disclosed. Accompanying the acquisition, Sangeeta Bhatia and Frank Slack will join Erkki Ruoslahti, MD, PhD; Tambet Teesalu, PhD; and Kazuki Sugahara, MD on Cend’s Scientific Advisory Board. Impilo scientific co-founder and Distinguished Professor at UC San Diego, Michael Sailor, PhD will join Cend’s Board of Directors. About Cend Therapeutics
September 15, 2020
Cend Therapeutics Announces Presentation and Abstract Publication at 2020 European Society for Medical Oncology (ESMO) Meeting
San Diego, September 15, 2020 – Cend Therapeutics, Inc., a clinical-stage biotech company, announced the publication of its abstract on the website of the annual meeting of the European Society for Medical Oncology. The poster that includes the detailed results will be presented at the virtual meeting on September 17, 2020.
The poster presenter and the Principal Investigator, Andrew Dean, MD of the St. John of God Hospital , Subiaco, Australia. Dr. Dean commented: “This first-in-human clinical study with CEND-1 provides encouraging results and highlights potential to enhance delivery of standard-of-care therapy for patients with metastatic pancreatic ductal adenocarcinoma (PDAC).”
“Inability to target delivery of drugs to primary tumor and metastases represents a significant factor limiting successful treatment of pancreatic cancer patients, who represent a high-need patient population. Our aim with CEND-1 is to provide a new tumor-targeted penetration capability to improve outcomes for pancreatic cancer patients,” commented Harri Jarvelainen, Chief Operating Officer at Cend Therapeutics.
The details of the poster are as follows:
Title: Phase I trial of the first-in-class agent CEND-1 in combination with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer
Presentation Number: 1528P
Speaker: Andrew Dean (Subiaco, WA, Australia)
About Cend Therapeutics
Cend is a clinical-stage biotech company focused on a novel approach to enhance and more selectively deliver treatments for solid tumor cancers. Poor penetration of drugs into tumors is a major issue in cancer therapy as it limits access and therefore efficacy of current therapies. The CendR Platform™ provides a targeted tissue penetration capability to specifically enhance drug delivery to tumors.
July 8, 2020
CEND Therapeutics Announces Board Member David Slack Will Succeed Erkki Ruoslahti as President & CEO
LA JOLLA, Calif., July 08, 2020 — Cend Therapeutics, Inc. (formerly DrugCendR, Inc.), a clinical-stage biotech company, announced today changes in the senior management of the company. David Slack, MBA will take over as President and CEO. Erkki Ruoslahti, MD, PhD, co-founding CEO will remain Chairman and serve as a senior advisor for the Company.
Mr. Slack has over 25 years of experience in the biotech and pharmaceutical industry having served in senior positions in several companies with focus on advancing innovative treatments for cancer patients. He has served as a member of the Cend Therapeutics board of directors since 2019. Most recently, Mr. Slack served as Chief Business Officer of Viracta Therapeutics. Prior to Viracta, he has served as co-founding CEO at Kinagen, Inc.; Vice President for Business Development at Ionis Pharmaceuticals; and in senior roles at Aventis Pharma, Rhone-Poulenc Rorer Pharmaceuticals and RPR Gencell.
Dr. Ruoslahti said: “I am very pleased to announce David’s appointment as CEO. He brings extensive senior management, financing and business development expertise to the Company. Cend has come a long way in the past 5 years; we have nearly completed a Phase 1 clinical trial with our lead investigational drug, CEND-1, in combination with standard-of-care chemotherapy for the treatment of metastatic pancreatic cancer, and we have an extensive preclinical-stage opportunities to apply our CendR drug delivery platform. David is the right leader to take the company through the next stage in its development.”
Mr. Slack said: “I am honored to take on this role with Cend. In addition to the encouraging results in the clinic, Erkki and the Cend team have laid the groundwork for broad applications of the Company’s technology, which opens up additional funding, product and partnering opportunities.”
May 5, 2020
Cend Therapeutics to Participate in BIO Digital Conference June 8-12, 2020
LA JOLLA, CA, May 5, 2020 — Cend Therapeutics Inc. a clinical stage oncology biotech, today announced that the company will attend the BIO Digital Conference on June 8-12, 2020.
Harri Jarvelainen, Chief Operating Officer will host virtual one-on-one meetings throughout the conference. Please contact us to arrange a meeting.
March 18, 2020
Cend Therapeutics Selected as a Buzz of BIO 2020 Finalist
Cend Therapeutics Inc, a clinical-stage oncology company developing innovative therapies to overcome drug delivery barriers in solid tumors, today announced that it was selected as one of the finalists of Buzz of BIO International Convention.
The Buzz of BIO contest provides great visibility and an excellent opportunity for companies looking to make the connections needed to take their product to the next phase. The contest helps to identify companies based in the U.S. with groundbreaking technologies that have the overall potential to improve lives in difficult-to-treat conditions.
To vote, visit https://www.bio.org/events/bio-international-convention/buzz-bio-voting and select Cend Therapeutics in the “Pipelines of Promise” category (companies are listed alphabetically). Harri Jarvelainen, COO of Cend Therapeutics, is available for meetings during the conference.
More than 200 scientific papers from laboratories all over the world provide non-clinical validation for Cend’s technology and show enhanced antitumor activity of a variety of therapeutics in a range of solid tumor types, documenting the broad applicability of Cend’s technology.
August 10, 2018
Cancer Research: Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies
August 10, 2018
Molecular Cancer Therapeutics: iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer:
August 24, 2017
Nature Communications: In vivo cation exchange in quantum dots for tumor-specific imaging
April 17, 2017
The Journal of Clinical Investigation: Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer
April 1, 2016
Advanced Drug Delivery Reviews: Tumor penetrating peptides for improved drug delivery
August 1, 2015
Cancer Research: Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma
March 18, 2014
British Journal of Cancer: Anticancer effects of gemcitabine are enhanced by co-administered iRGD peptide in murine pancreatic cancer models that overexpressed neuropilin-1
May 21, 2010
Science: Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs